The game will be played Dec. 21 at the Ford Center in Oklahoma City as a doubleheader with Oklahoma's game against Tulsa.
The Cowboys have never played the Hoyas.
Georgetown is coached by John Thompson III, son of legendary Hoyas coach John Thompson, who led the team to the 1984 national title. Oklahoma State will be in its first full season under head coach Sean Sutton, son of legendary coach Eddie Sutton.
The Hoyas are coming off a trip to the Sweet 16, where they lost to eventual national champion Florida.